Skip to main content
. 2019 Apr 25;3(2):pkz014. doi: 10.1093/jncics/pkz016

Table 2.

Factors associated with changes in SMI during initial therapy

Variables Univariate analysis
 Multivariable model 1
 Multivariable model 2
β 95% CI β 95% CI β 95% CI
Measured at start of initial therapy
 Sex, female vs male 1.67 −0.16 to 3.50 −1.52 −3.60 to 0.57 1.75 −0.06 to 3.57
 Age, y −0.02 −0.12 to 0.08 −0.05 −0.15 to 0.06 — —
 Initial BMI, kg/m2 −0.38 * −0.60 to −0.17 −0.05 −0.29 to 0.19 — —
 Initial SMI, cm2/m2 −0.32 * −0.42 to −0.22 −0.32 * −0.45 to −0.19 — —
 Smoking status, yes vs no −2.64 * −5.17 to −0.12 −2.74 * −5.29 to −0.19 — —
 Initial level of leukocytes,*†109/L 0.06 −0.01 to 0.12 0.03 −0.05 to 0.11 — —
 Initial level of thrombocytes,†*103/mm3 0.09 * 0.03 to 0.15 0.03 −0.05 to 0.11 — —
 Initial level of LDH,† U/L 0.003 −0.03 to 0.04 −0.01 −0.05 to 0.02 — —
 Initial level of albumin, g/L 0.01 −0.23 to 0.24 0.10 −0.19 to 0.40 — —
 Primary tumor sidedness, left vs right 0.34 −1.71 to 2.39 1.09 −0.93 to 3.11 — —
 Interval of metastases, metachronous vs synchronous −3.61 * −5.64 to −1.58 −3.02 * −5.50 to −0.53 — —
 Primary tumor resection, yes vs no 0.23 −1.58 to 2.04 2.17 * 0.13 to 4.21 — —
 Prior adjuvant therapy, yes vs no −0.43 −2.31 to 1.44 0.06 −1.79 to 1.91 — —
Measured after initial therapy
 Best response to initial therapy, stable disease vs CR or PR −2.56 * −4.43 to −0.69 — — −2.48 * −4.33 to −0.62
 Dose reduction during initial therapy, yes vs no −0.92 −2.69 to 0.86 — — −0.95 −2.71 to 0.81
*

Statistically significant association (P ≤ .05). Results are presented as regression coefficients (β), representing the average percentage change in SMI during initial treatment per unit (or per percentage for leukocytes, thrombocytes, and LDH) increase of the corresponding variable, including 95% confidence intervals (95% CI). Model 1 contains only variables measured at start of initial therapy, and model 2 contains variables measured after initial therapy. BMI = body mass index; CR = complete response; LDH = lactate dehydrogenase; PR = partial response; SMI = skeletal muscle index.

†

Analyzed as log-transformed variable.