Table 1.
Correlation between bone marrow disseminated tumor cells and circulating tumor cells detection in breast cancer*
| References | No. of patients | Stage | Tech. | Conc. % | Correlation P | Detection rate, % |
Prognostic impact |
||
|---|---|---|---|---|---|---|---|---|---|
| CTC | DTC | CTC | DTC | ||||||
| Pierga et al. (2004) (50) | 114 | I–IV | ICC | 66 | <.001 | 24 | 59 | n.s. | DFS |
| Wiedswang et al. (2006) (51) | 341 | I–III | ICC + IMS | 81 | n.s. | 10 | 14 | DFS OS | DFS OS |
| Benoy et al. (2006) (52) | 148 | I–IV | RT-PCR | 68 | n.s. | 15 | 28 | n.s. | OS |
| Fehm et al. (2009) (53) | 414 | I–III | ICC/RT-PCR | 72 | .05 | 13 | 24 | n.a. | n.a. |
| Daskalaki et al. (2009) (54) | 165 | I–II | RT-PCR | 94 | <.001 | 55 | 58 | OS | OS |
| Banys et al. (2012) (55) | 209 | I–III | ICC/RT-PCR | 74 | .03 | 21 | 15 | n.a. | n.a. |
| Molloy et al. (2011) (56) | 733 | I–II | ICC/RT-PCR | 80 | .01 | 8 | 12 | DFS OS | DFS OS |
| Schindlbeck et al. (2013) (40) | 202 | I–IV | ICC/CellS | 71 | .002 | 20 | 28 | OS | n.s. |
| Hartkopf et al. (2014) (57) | 178 | IV | ICC/CellS | 61 | n.s. | 52 | 36 | DFS OS | OS |
*
Only studies with >100 patients have been included. CellS = CellSearch; conc = concordance rate; CTC = circulating tumor cells; DFS = disease-free survival; DTC = disseminated tumor cell; ICC = immunocytostaining; IMS = immunomagnetic selection; n.a. = not available; n.s. = not statistically significant; OS = overall survival; pts = patients; RT-PCR = reverse transcription polymerase chain reaction; tech = techniques used.