Figure 4.
Significant interactions of 6AP with key nucleotides in GR: (A) and (B) respectively indicating hydrophobic interactions and hydrogen bonding interactions of 6AP with nucleotides in the WT GR; (C) and (D) separately depicting hydrophobic interactions and hydrogen bonding interactions of 6AP with nucleotides in GR with mutations U25A/A46G/C74U; (E) and (F) respectively describing hydrophobic interactions and hydrogen bonding interactions of 6AP with nucleotides in GR with mutations A24U/U25A/A46G/C74U. The key nucleotides and 6AP are shown in stick modes and water molecules in the forest color balls. The magenta balls represent pseudoatoms forming hydrophobic interactions between 6AP and nucleotides.