Table 2. Domains identified in A2ML isoforms (Tenualosa ilisha) as compared to Homo sapiens (Accession No.XM_017018870.1).
| Organism/Tissue | ID | No of domains | A2M_N (amino acid position) |
A2M_N2 (amino acid position) |
Bait region | A2M (amino acid position) |
Thiol-ester cl (amino acid position) |
A2M_Comp (amino acid position) |
A2M_Recep (amino acid position) |
|---|---|---|---|---|---|---|---|---|---|
| Homo sapiens | A2ML1.a# | 6 | 121–238 | 453–601 | 690–728 | 736–826 | 959–988 | 1008–1253 | 1352–1449 |
| T. ilisha | Consensus | 6 | 126–221 | 498–647 | 723–770 | 777–866 | 999–1028 | 1048–1303 | 1412–1500 |
| Liver | |||||||||
| IsoformX1 | 20636 | 3 | 126–221 | 470–619 | 695–742 | 749–838 | 971–1000 | 1020–1275 | 1384–1472 |
| IsoformX2 | 13703 | 2 | 126–221 | 471–554 | - | - | - | - | - |
| IsoformX3 | 2188 | 2 | 126–221 | 498–647 | - | - | - | - | - |
| IsoformX4 | 19153 | 3 | - | 6–155 | 230–266 | 273–362 | 495–524 | 544–799 | 910–998 |
| IsoformX5 | 27606 | 4 | - | - | - | 100–189 | 322–351 | 371–602 | 713–801 |
| IsoformX6 | 2280 | 3 | - | - | - | - | 1–23 | 43–298 | 409–497 |
| IsoformX7 | 9113 | 3 | - | - | - | - | 1–23 | 43–274 | 385–470 |
| Ovary | |||||||||
| IsoformX8 | 19791 | 2 | - | - | 1–21 | 22–111 | 244–273 | 310–547 | 658–682 |
| IsoformX9 | 29945 | 3 | - | - | - | - | 1–23 | 43–298 | 409–497 |
| IsoformX10 | 136214 | 1 | - | - | - | - | - | - | 1–87 |
| IsoformX11 | 29646 | 3 | - | - | - | - | 75–104 | 124–379 | 490–578 |
| Testes | |||||||||
| IsoformX12 | 18316 | 4 | - | - | 1–21 | 22–111 | 244–273 | 293–548 | 659–747 |
# Sequence obtained from NCBIAceView database from https://www.ncbi.nlm.nih.gov/ieb/research/acembly/.
A2M_N: MG2 domain of alpha-2-macroglobulin
A2M_N_2: Alpha-2-macroglobulin family N-terminal region
A2M: Alpha-2-macroglobulin family
Thiol-ester_cl: Alpha-2-macroglobulin thiol-ester bond forming region
A2M_Comp: A-macroglobulin complement component