Table 2.
Univariate and multivariate analyses of various prognostic parameters in HCC
| Parameters | Regression coefficient β | HR (95% CI) | P-value |
|---|---|---|---|
| Univariate analysis | |||
| Gender | −0.309 | 0.734 (0.513–1.05) | 0.091 |
| Age | −0.026 | 0.974 (0.682–1.391) | 0.885 |
| Smoking | 0.212 | 1.237 (0.845–1.81) | 0.274 |
| Alcoholism | 0.025 | 1.025 (0.702–1.496) | 0.898 |
| HBsAg | −0.003 | 0.997 (0.668–1.486) | 0.997 |
| AFP | 0.5 | 1.648 (1.112–2.444) | 0.013 |
| Tumor diameter | 0.286 | 1.331 (0.889–1.993) | 0.165 |
| TNM | 0.374 | 1.454 (1.01–2.093) | 0.044 |
| Differentiation | 0.306 | 1.359 (0.938–1.967) | 0.105 |
| BCLC stage | −0.039 | 0.962 (0.76–1.218) | 0.747 |
| ALT | 0.052 | 1.053 (0.732–1.514) | 0.781 |
| AST | 0.191 | 1.21 (0.827–1.771) | 0.326 |
| Liver cirrhosis | 0.232 | 1.261 (0.871–1.826) | 0.22 |
| Hsa_circ_0003998 expression | −0.505 | 0.604 (0.422–0.864) | 0.006 |
| Multivariate analysis | |||
| AFP | 0.538 | 1.713 (1.153–2.544) | 0.008 |
| Hsa_circ_0003998 expression | −0.539 | 0.583 (0.407–0.836) | 0.003 |
Note: Bold values indicate P<0.05.
Abbreviations: HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; AFP, alpha-fetoprotien; BCLC, Barcelona clinic liver cancer; ALT, alanine aminotransferase; AST, aspartate transaminase; HR, hazard ratios; CI, confidence interval.