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. Author manuscript; available in PMC: 2019 Jul 23.
Published in final edited form as: Comput Toxicol. 2018;7:58–67. doi: 10.1016/j.comtox.2018.07.002

Table 1.

Daily oral exposure TTC values for all applicable chemicals below which there would be no appreciable risk to human health.

Type of substance μg/person/day (μg/kg-day for 60 kg adult)
Alerts for potential genotoxic carcinogenicity Kroes: 0.15 (0.0025 μg/kg-day) ICH: 1.5 (0.025 μg/kg-day)a
4Acetylcholinesterase inhibitors (AChEI) (Organophosphates (OPs)/carbamates) 18 (0.3 μg/kg-day)
Cramer Class III 90 (1.5 μg/kg-day)b
Cramer Class II 540 (9.0 μg/kg-day)
Cramer Class I 1800 (30 μg/kg-day)
a

higher threshold (1.5 μg/person per day) is used for pharmaceutical impurities that are mutagenic or that are suspected of being mutagenic (International Conference on Harmonization (ICH) [44]).

b

Exclusion of organophosphates from the Munro et al. [42] Class III dataset would give rise to a 5th percentile NOAEL of 0.3 mg/kg-day which would yield a corrected Class III TTC of 180 μg/person-day instead of the 90 μg/person-day [31].