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. 2019 Jul 2;6(5-6):317–336. doi: 10.18632/oncoscience.482

FIGURE 1. Gene alterations in Akt pathway human prostate adenocarcinoma.

FIGURE 1

(A) Oncoprint showing genomic alterations in the Akt pathway genes in human prostate adenocarcinoma samples based on the integrative genomic profiling performed by the MSKCC study (Taylor BS et al, Cancer Cell, 2010). (B) Kaplan–Meier survival analysis showing decreased disease-free survival in patients with observed Akt pathway alterations (indicated in red) compared to the unaltered group (indicated in blue). (C) A plot showing the relationship between Akt1 mRNA abundance and copy-number alteration (CAN) in the Akt1 gene in human prostate adenocarcinoma. (D) Chart showing the overall mRNA expression of Akt1, Akt2, and Akt3 in the prostatic adenocarcinoma tissues with observed Akt pathway alterations compared to the un-altered group.