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. 2019 Jul 2;6(5-6):317–336. doi: 10.18632/oncoscience.482

FIGURE 2. Gene alterations in Akt pathway in castration-resistant neuroendocrine PCa.

FIGURE 2

(A) Oncoprint showing genomic alterations in the Akt pathway genes in human castration-resistant neuroendocrine PCa samples based on the genomic profiling by the Trento/Cornell/Broad study (Beltran H et al, Nat Med, 2016). (B) A plot showing the relationship between Akt1 mRNA abundance and copy-number alteration (CAN) in the Akt1 gene in human castration-resistant neuroendocrine PCa. (C) Chart showing the overall mRNA expression of Akt1, Akt2, and Akt3 in neuroendocrine PCa samples with observed Akt pathway alterations compared to the un-altered group.