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. 2019 Jul 2;6(5-6):317–336. doi: 10.18632/oncoscience.482

FIGURE 5. Gene alterations in Akt pathway in human advanced PCa.

FIGURE 5

(A) Oncoprint showing genomic alterations in the Akt pathway genes in human advanced (metastatic castration-resistant) PCa tissues based on the genomic analysis performed by the MSKCC/UMICH study (Robinson D et al, Cell, 2015). (B) A plot showing the relationship between Akt1 mRNA abundance and copy-number alteration (CAN) in the Akt1 gene in human advanced PCa. (C) Chart showing the mean mRNA expression of Akt1, Akt2 and Akt3 in the advanced PCa tissues with observed Akt pathway alterations compared to the un-altered group.