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. 2019 Jul 2;6(5-6):317–336. doi: 10.18632/oncoscience.482

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Copyright: © 2019 Alwhaibi et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Oncoprint showing genomic alterations in the Akt pathway genes in human primary (non-metastatic) PCa tissues based on the analysis by the cancer genome atlas research network (TCGA, Cell, 2015). (B) Kaplan–Meier survival analysis showing decreased disease-free survival in patients with observed Akt pathway alterations (in red) compared to the un-altered (in blue) group. (C) Kaplan–Meier survival analysis showing decreased overall survival in patients with observed Akt pathway alterations compared to the un-altered group. (D) A plot showing the relationship between Akt1 mRNA abundance and copy-number alteration (CAN) in the Akt1 gene in human primary PCa. (E) A plot showing the relationship between Akt1 protein expression and copy-number alteration (CAN) in the Akt1 gene in human primary PCa. (F) Chart showing the mean mRNA expression of Akt1, Akt2 and Akt3 in the PCa tissues with observed Akt pathway alterations compared to the un-altered group.