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. 2019 Jul 2;6(5-6):317–336. doi: 10.18632/oncoscience.482

FIGURE 9. EMT is positively correlated to higher Gleason score and PCa metastasis with no change in the Akt1 expression.

FIGURE 9

(A-D) Castration-resistant PCa from patients in the MSKCC/UMICH study (Robinson D et al, Cell, 2015) stratified based on the anatomic site [prostate and others (bone, muscles, neck, chest wall, thoracic epidural, liver, bladder, penis, pelvis, lymph node, perirectal, retroperitoneum and soft tissue) group] showed no change in Akt1 mRNA level with a trend toward elevation of TGFβ1, CDH2 (N-cadherin) and Snail in the others compared to the prostate group. (E-H) Primary prostate adenocarcinoma from patients in the cancer genome atlas study (TCGA, Cell, 2015) stratified based on Gleason score [higher (8-10) and lower (6-7) group] showed no change in Akt1 mRNA level with a significant increase in TGFβ1 and CDH2 (N-cadherin) and a trend toward elevation of Snail in the higher compared to the lower Gleason score group. *P < 0.05; $P < 0.01; Unpaired Student t-test for two groups analysis (GraphPad Prism 6.01). Data are presented as means ± SD.