. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Neurobiol Dis. 2018 Sep 13;126:85–104. doi: 10.1016/j.nbd.2018.09.011

Table 7: Multi-System Atrophy.

In this table, all studies indexed by PubMed from 2012 to 2018 with intra-arterial/intravenous injections of mesenchymal stem cells to treat Multiple Systems Atrophy are referenced. In these two studies, stem cell transplant in mice and in humans with MSA both ameliorated motor deficits and improved behavioral outcomes.

Author	Model	Cell type	Cell Quantity	Outcome
Na Kim et al., 2017	adult male or female Sprague Dawley rats	Human MSCs	4 × 10⁷ cells/60 kg	Increased nigrostriatal neuronal survival and a coincidental increase in motor behavior.
Lee et al., 2012	MSA patients, n=33	Autologous MSCs	4 × 10⁷/injection	Possible delay in neurological deficits.

MSA – multi-system atrophy; MSC – mesenchymal stem cells