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. 2019 May 29;569(7758):655–662. doi: 10.1038/s41586-019-1237-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, Subset of the network in Fig. 4c showing metagenomic abundances (octagons) and expression levels (hexagons) of Subdoligranulum, Roseburia spp. and F. prausnitzii and their neighbours (three functionally associated microbial hubs selected for further investigation based on anti-inflammatory associations in the literature, see text). b, The host expression-related subnetwork of the ‘unadjusted’ association network (Extended Data Fig. 9, Supplementary Discussion). Sample counts in Fig. 1b, c.