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Methods used for the preparation of 21. Reagents and conditions: a) HOBT, EDC, DIPEA (82%); b) TFA, DCM (100%); c) (i) BH3·THF, THF, (ii) Boc2O, DCM (39%); d) 20% Pd(OH)2/C, H2, ethanol e) 2-phenethyl-4-phenylbutanoic acid, PyBrOP, Et3N, DCM (78%); f) TFA, DCM (100%)
