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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2019 Jun 4;27(15):3254–3278. doi: 10.1016/j.bmc.2019.06.003

Scheme 15.

Scheme 15.

Methods used for the preparation of 24. Reagents and conditions: a) Boc2O, Et3N, DCM (56%); b) 20% Pd(OH)2/C, H2, ethanol (100%); c) HOBT, EDC, DIPEA (34%); d) TFA, DCM; e) BH3·THF, THF (ii) Boc2O, DCM (10%); f) TFA, DCM (67%)