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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2019 Jun 4;27(15):3254ā€“3278. doi: 10.1016/j.bmc.2019.06.003

Scheme 1.

Scheme 1.

General method used for the preparation of N,Nā€™-diprotected triaminopentane derivatives. Reagents and conditions: a) i) N-methylmorpholine, isobutylchloroformate, DME, ii) NaBH4, DME/H2O; b) phthalimide, DIAD, PPh3, THF; c) hydrazine, methanol.