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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2019 Jun 4;27(15):3254ā€“3278. doi: 10.1016/j.bmc.2019.06.003

Scheme 2.

Scheme 2.

General method for forming the amide derivatives 2ā€“7 using Nā€™,Nā€-diprotected 2,5-diaminopentylamine and the appropriate acid. Reagents and conditions: a) EDC, HOBT, 2,6-lutidine; b) one step deprotection (20% Pd(OH)2/C, H2, ethanol) or a 2-step deprotection (i)TFA, DCM; ii) 20% Pd(OH)2/C, H2, ethanol).