Skip to main content
. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2019 Jun 4;27(15):3254–3278. doi: 10.1016/j.bmc.2019.06.003

Table 3.

Impact of 15–21 on the Activity of Clarithromycin against E. coli ATCC 25922.

graphic file with name nihms-1533051-t0022.jpg
Compound* X Y Z R1 R2 MIC of Clarithromycin (μg/ml) Fold Reduction in MIC
15 CH3 H H H H 32 2
16 CH3 CH3 H H H 32 2
17 NH2 H H H H 61 1
18 CNH(NH2) H H H H 16 4
19 H H H CH3 H 64 1
20 H H H CH3 CH3 32 2
21 H H CH3 H H 64 1
*

All compounds were present at 12.5 μg/ml, a concentration at least four-fold lower than the intrinsic MIC of each compound (given in Table S1).