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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Bioorg Med Chem. 2019 Jun 4;27(15):3254–3278. doi: 10.1016/j.bmc.2019.06.003

Table 4.

Impact of 7 and 22 on the Activities of the Antibiotics Minocycline, Novobiocin, Clindamycin, and Azithromycin against E. coli ATCC 25922

Antibiotic Intrinsic MIC (μg/ml) In the Presence of 7 @ 12.5 μg/ml In the Presence of 22 @ 12.5 μg/ml
MIC (μg/ml) Fold Reduction in MIC MIC (μg/ml) Fold Reduction in MIC
Minocycline 1 0.125 8 0.25 4
Novobiocin 64 0.5 128 2 32
Clindamycin 128 8 16 8 16
Azithromycin 8 0.125 64 0.5 16