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. 2019 Feb 7;16(8):509–520. doi: 10.1038/s41571-019-0177-5

Fig. 3. The cellular origins of brain tumours.

Fig. 3

Brain tumours are thought to arise from a transformed and malignant brain tumour hierarchy generated from transformed neuronal stem cells. Nonmalignant and malignant stem cells in the brain are believed to reside in perivascular niches formed by the blood vessels of the brain. Unaddressed key research questions that could provide a better understanding of brain tumour development and treatment are shown in the thought bubbles.