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. Author manuscript; available in PMC: 2020 Jul 22.
Published in final edited form as: Dev Cell. 2019 Jun 6;50(2):212–228.e6. doi: 10.1016/j.devcel.2019.05.015

Figure 5. Moderate p53 activation triggers apoptosis in certain cell populations and restrains proliferation in others.

Figure 5

(A). RNA-seq experiment. n=5 embryos per genotype. FDR: false discovery rate, FC: fold change.

(B-D) Immunofluorescence staining for p53, BrdU and Cleaved Caspase 3 (CC3) on transverse sections of E9.5–10.5 embryos counterstained with DAPI (blue). Arrows indicate CC3-positive cells. Bar graphs represent mean ± SD. AHF: anterior heart field, RV: right ventricle. n=3–4 per genotype. *p<0.05. Scale bar: 100µm.

(E) Choice of cell fate following moderate p53 activation in different cell compartments.

See also Figure S3, Figure S4, Figure S5, Figure S6, Table S2, Table S3.