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. Author manuscript; available in PMC: 2020 Jul 23.
Published in final edited form as: J Cell Physiol. 2019 Jan 23;234(9):14422–14431. doi: 10.1002/jcp.28166

FIGURE 2.

FIGURE 2

Col2a1-Cre mediates recombination in the majority of cells in IVD tissues at postnatal stages. (a,b) Fluorescence images of EGFP/mTomato on intervertebral disc sections from 2-week-old (a) and 2-month-old (b) Col2a1-Cre; R26-mTmG mice. (c–h) Higher magnification EGFP/mTomato images for CEP/GP (c,d), AF (e,f), and NP (g,h) from 2-week-old (c,e,g) and 2-month-old (d,f,h) Col2a1-Cre; R26-mTmG mice. Red: membrane-targeted tdTomato; Green: membrane-targeted EGFP. CEP: cartilaginous endplate; GP; growth plate cartilage; IAF: inner annulus fibrosus; IVD: intervertebral disc; NP: nucleus pulposus; OAF: outer annulus fibrosus. Images shown were representative results from three independent mice analyzed [Color figure can be viewed at wileyonlinelibrary.com]