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. 2019 Jul 23;9:10635. doi: 10.1038/s41598-019-46964-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of Lactobacillus and Clostridium colonization according to perinatal antibiotic exposure during the whole study period in control (NN), IAP (YN), postnatal (NY),and IAP + Postnatal groups (YY). Infants in NY and YY groups received Lactobacillus rhamnosus probiotic during antibiotic treatment according to routine clinical treatment procedure in the hospital. The statistical comparisons using the data from the whole study period were performed using linear mixed model (P values in the text).