Table 2.

miR-424-3p expression and significant clinicopathological variables (Multivariate model, Cox regression, backward conditional).

Characteristic	No	BF (200 events)			CF (56 events)			PCD (18 events)
		HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age				NS			NS			NS
≤65 years	264
>65 years	135
pT-stage				0.035			NS			NS
pT2	275	1
pT3a	85	1.42	(0.69–2.86)	0.343
pT3b	39	0.52	(0.32–0.83)	0.006
Preoperative PSA				NS			NS			0.023
PSA <10	224							1
PSA >10	175							0.21	(0.06–0.81)
Gleason grade group				0.016			0.001			NS
1 (3+3)	126	1			1
2 (3+4)	231	2.13	(0.47–9.70)	0.329	0.19	(0.03–1.19)	0.076
3 (4+3)	115	2.90	(0.66–12.82)	0.161	0.56	(0.12–2.62)	0.465
4 (4+4)	24	4.25	(0.82–22.13)	0.085	1.27	(0.20–8.18)	0.804
5 (≥9)	3	4.57	(1.00–20.80)	0.050	2.32	(0.49–11.03)	0.290
Tumor size				NS			NS			NS
0–20 mm	169
>20 mm	230
PNI				0.008			NS			NS
No	298	1
Yes	101	0.62	(0.44–0.83)
Non-apical PSM				0.003			NS			NS
No	284	1
Yes	115	0.58	(0.41–0.83)
Apical PSM				0.02			NS			NS
No	247	1
Yes	152	1.52	(1.07–2.15)
Vascular infiltration				NS			0.008			NS
No	365				1
Yes	34				0.39	(0.19–0.79)
miR-424-3p				NS			0.018			NS
Low	200				1
High	204				0.44	(0.22–0.87)

Abbreviations: BF = biochemical failure; CF = clinical failure; PCD = prostate cancer death; PSA = prostate specific antigen; PNI = perineural infiltration, PSM = positive surgical margin; NS = not significant.