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. 2019 Jul 23;9:10675. doi: 10.1038/s41598-019-47034-6

Table 2.

Strength of the spatial correlation of λ substitution rates in the BTB and KREP domains of K13 and other proteins.

Protein domain l σ log Bayes factor
K13BTB-KREP 5 0.9 30.84
K13KREP 3 0.9 20.67
SHKBP1BTB 11 1.5 13.27
KCTD17BTB 7 1.3 9.69
KEAP1KREP 5 1.7 44.06
KLHL2KREP 7 1.5 93.54
KLHL3KREP 7 1.3 79.47
KLHL12KREP 7 1.5 25.18

l, strength of the spatial correlation of site-specific substitution rates λ over protein tertiary structure, in Å; σ, signal standard deviation measuring the variability of λ substitution rates across amino acid sites; log Bayes factor, statistical significance of the spatial correlation of site-specific substitution rates λ. A log Bayes factor ≥ 8 identifies a significant spatial correlation of site-specific substitutions rates λ in protein tertiary structure (conservative cutoff as suggested by FuncPatch’ authors)33.