Table 2.
Strength of the spatial correlation of λ substitution rates in the BTB and KREP domains of K13 and other proteins.
| Protein domain | l | σ | log Bayes factor |
|---|---|---|---|
| K13BTB-KREP | 5 | 0.9 | 30.84 |
| K13KREP | 3 | 0.9 | 20.67 |
| SHKBP1BTB | 11 | 1.5 | 13.27 |
| KCTD17BTB | 7 | 1.3 | 9.69 |
| KEAP1KREP | 5 | 1.7 | 44.06 |
| KLHL2KREP | 7 | 1.5 | 93.54 |
| KLHL3KREP | 7 | 1.3 | 79.47 |
| KLHL12KREP | 7 | 1.5 | 25.18 |
l, strength of the spatial correlation of site-specific substitution rates λ over protein tertiary structure, in Å; σ, signal standard deviation measuring the variability of λ substitution rates across amino acid sites; log Bayes factor, statistical significance of the spatial correlation of site-specific substitution rates λ. A log Bayes factor ≥ 8 identifies a significant spatial correlation of site-specific substitutions rates λ in protein tertiary structure (conservative cutoff as suggested by FuncPatch’ authors)33.