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. 2019 Jul 23;9:10657. doi: 10.1038/s41598-019-47082-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Cell density relative to the maximum density in the stack, as a function of distance from the cavity base, for 40 µm honeycombs on a single implant. Solid lines and shaded regions represent the mean and standard deviation of all analyzed cavities, respectively. Extension of electric field to 40 µm within the safe charge injection limit (dashed blue line) enables activation of cells located above the wells. b) Fraction of the INL cells within the honeycombs of 40, 30, and 20 µm in width represents 51, 46 and 53% of the total INL volume, respectively.