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. 2019 Jul 23;9:10624. doi: 10.1038/s41598-019-47024-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A,B) Memory subset distribution of TIGIT+, HCV-specific CD4+ T cells of HCV patients with acute, chronic and spontaneously resolved infection. The differentiation markers CD45RO and CCR7 were used to analyse the ex vivo expression of TIGIT+ HCV-specific MHC class II tetramer+ CD4+ T cells within different memory T cell subsets. (A) Representative large dot plots depicting the memory subset distribution of TIGIT+ HCV-specific MHC class II tetramer+ CD4+ T cells (red) on an overlay of gated total CD4+ cells (grey) of patients with acute, chronic and spontaneously resolved HCV infection; memory subset definition: CCR7−/CD45RO–terminal effector T cells-T_EMRA; CCR7+/CD45RO–naïve T cells-T_naïve; CCR7−/CD45RO+–effector memory–T_EM; CCR7+/CD45RO+–central memory–T_CM. (B) Comparison of the TIGIT receptor expression of HCV-specific MHC class II tetramer+ CD4+ T cells and different memory T cell subsets in patients with acute (n = 10), chronic (n = 11), and spontaneously resolved (n = 8) infection. P values were calculated by the Tukey’s multiple comparison test. P-values smaller than 0.05 were considered significant, where *^,** and *** indicate p-values between 0.01 to 0.05, 0.001 to 0.01 and 0.0001 to 0.001 respectively.