Table 1.
Clinical, virological, and immunological patient characteristics.
| Infection status | Age/Sex | HLA-class II | Genotype | Peak VL (IU/ml) | VL (IU/ml)* | Peak ALT (U/l) | ALT (U/l)* |
Longitudinal samples | Outcome | Therapy |
|---|---|---|---|---|---|---|---|---|---|---|
| aHCV 1 | 68/f | DRB1*01:01, *14:01 | 1a | / | 4000000 | / | 51 | yes | cHCV/SVR | peg-IFN/RBV (24 W) |
| aHCV 2 | 42/m | DRB1*14:01, *15:01 | 1a | 70000 | 70000 | 558 | 558 | no | cHCV | / |
| aHCV 3 | 51/f | DRB1*03:01, *15:01 | 2b | 8000 | 8000 | 1548 | 798 | no | Sp. R | / |
| aHCV 4 | 54/f | DRB1*01:02,*03:01 | 3a | 4000000 | 30000000 | 1273 | 1084 | yes | Sp. R | / |
| aHCV 5 | 47/f | DRB1*01:02, *15:01 | n.a. | Llod | Llod | 63 | 63 | yes | Sp. R | / |
| aHCV 6 | 22/f | DRB1*01:01, *03:01 | 1a | 400000 | 30000 | 368 | 40 | yes | cHCV/SVR | peg-IFN/RBV (24 W) |
| aHCV 7 | 32/m | DRB1*13:02,*15:01 | n.a. | 70000 | 70000 | 1317 | 91 | no | Sp. R | / |
| aHCV 8 | 44/m | DRB1*01:01, *03:01 | 1a | 30000000 | 90000 | 4316 | 1762 | yes | cHCV/SVR | peg-IFN/RBV (24 W) |
| aHCV 9 | 38/f | DRB1*03:01, 15:06 | 3 | 2070000 | 30500 | 521 | 115 | no | cHCV | |
| aHCV 10 | 39/m | DRB1*04:01, *15:01 | 1a | 18040000 | 140 | 2387 | 51 | yes | cHCV/SVR | peg-IFN/RBV (24 W) |
| rHCV 11 | 38/m | DRB1*11:01, *13:02 | n.a. | Llod | Llod | 32 | 22 | no | / | / |
| rHCV 12 | 36/m | DRB1*01:01, *11:01 | n.a. | Llod | Llod | 23 | 23 | no | / | / |
| rHCV 13 | 36/m | DRB1*07:01,*15:01 | n.a. | Llod | Llod | 66 | 43 | no | / | / |
| rHCV 14 | 48/f | DRB1*01:01,*- | n.a. | Llod | Llod | 15 | 10 | no | / | / |
| rHCV15 | 51/f | DRB1*01:01,*14:01 | n.a. | Llod | Llod | 94 | 48 | no | / | / |
| rHCV 16 | 26/m | DRB1*11:02, *12:01 | n.a. | Llod | Llod | 90 | 86 | no | / | / |
| rHCV 17 | 44/m | DRB1*01:01, *27:05 | n.a. | Llod | Llod | 84 | 20 | no | / | / |
| rHCV 18 | 68/m | DRB1*08:03, *11:01 | n.a. | Llod | Llod | 32 | 30 | no | / | / |
| cHCV 19 | 65/m | DRB1*11:01,*15:01 | 1a | 1000000 | 800000 | 100 | 100 | no | / | / |
| cHCV 20 | 60/f | DRB1*04:01, *15:01 | 1b | 9000000 | 9000000 | 68 | 54 | no | / | / |
| cHCV 21 | 28/f | DRB1*13:01, *15:01 | 1b | 2000000 | 2000000 | 43 | 43 | yes | SVR | Ledipasvir/Sofusbuvir (12 W) |
| cHCV 22 | 56/m | DRB1*11:02, *15:01 | 1a | 30000 | 10000 | 374 | 75 | no | / | / |
| cHCV 23 | 63/f | DRB1*07:01, *15:01 | 1b | 10000000 | 2000000 | 138 | 54 | yes | SVR | Ledipasvir/Sofosbuvir (12 W) |
| cHCV 24 | 43/m | DRB1*04:04,*15:01 | 1b | 6000000 | 5230000 | 208 | 128 | yes | SVR | Ombitasvir/Paritaprevir/Ritonavir+Dasabuvir (12 W) |
| cHCV 25 | 43/f | DRB1*13:01, *15:03 | 1a | 8741517 | 2884373 | 43 | 43 | no | / | / |
| cHCV 26 | 55/m | DRB1*15:01, *13:01 | 3a | 2775 | 2775 | 91 | 65 | no | / | / |
| cHCV 27 | 40/f | DRB1*03:01,*15:01 | 3 | 4330000 | 4330000 | 42 | 30 | no | / | / |
| cHCV 28 | 39/f | DRB1*04:08, *15:02 | 3 | 24300000 | 24300000 | 71 | 50 | no | / | / |
| cHCV 29 | 46/m | DRB1*07:01, *15:01 | 3 | 15900000 | 13300000 | 208 | 127 | yes | SVR | Sofusbuvir/Velpatasvir (12 W) |
| tHCV 30 | 62/m | DRB1*01:01 | n.a. | Llod | Llod | 58 | 58 | no | SVR | peg-IFN/RBV (24 W) |
| tHCV 31 | 37/m | DRB1*01:01, *07:01 | 3 | 25100000 | 26 | 319 | 43 | no | SVR | Sofusbuvir/Velpatasvir (12 W) |
| tHCV 32 | 37/m | DRB1*15:01, - | 3 | 17800000 | Llod | 25 | 25 | no | SVR | Sofusbuvir/Velpatasvir (12 W) |
| tHCV 33 | 52/m | DRB1*01:01, *11:01 | 1a | 2000000 | Llod | 272 | 107 | no | SVR | peg-IFN/RBV (48 W) |
| tHCV 34 | 39/m | DRB1*07:01, *11:01 | 3 | 850000 | Llod | 157 | 25 | no | SVR | Sofusbuvir/Velpatasvir (12 W) |