Skip to main content
. 2019 Jul 23;9:10689. doi: 10.1038/s41598-019-47069-9

Figure 9.

Figure 9

Silencing the CKIIα gene blocked the infection of human MDM by HIV-1 CRF02_AG isolates, but had no effect on clade-B HIV-1 infection. (AD) Following silencing of CKIIα and CKIIβ genes, MDM were infected with CRF02_AG or clade-B HIV-1 isolates (3 different isolates for each subtype, each isolate tested in triplicate) and RT activity measured from day-5 to day-21 p.i. (A,B) RT activity in MDM with CKIIα gene silenced. (C,D) RT activity in MDM with CKIIβ gene silenced. Controls are non-HIV infected (mock-infected) MDM, “S” are MDM transduced with scrambled shRNA; “sh” are MDM transduced with CKIIα or CKIIβ shRNA. *P < 0.05, #P < 0.0001, compared to infected MDM transduced with similar concentrations of scrambled shRNA (S).