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. 2019 Jul 23;9:10656. doi: 10.1038/s41598-019-46933-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Muc-1^KO BMDM express lower levels of the integrin VLA-4. (A) BMDMs from WT and Muc-1^KO mice were treated with or without LPS (100 ng/ml) for 16 hours and cells were processed for flow cytometric analysis. CD11b+Gr1+ cells were gated and the expression levels of VLA-4 were compared. Flow cytometric data shown are representative of 3 independent experiments. (B) Quantitative data showed that the median fluorescent intensity (MFI) of VLA-4 expression levels were compared between the WT and Muc-1^KO BMDMs. Quantification data shown are mean ± SD and represent three independent experiments. **p ≤ 0.01 indicates statistical significance. (C) IHC staining of VLA-4 on pancreas sections from WT and Muc-1^KO mice with CVB3 infection 8-days post-inoculation.