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. 2019 Jul 23;9:10669. doi: 10.1038/s41598-019-46956-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MTP18 expression is regulated in RGCs by KLFs and through development. (a) MTP18 mRNA expression after lentivirus mediated KLF 11, -7 and -9 expression, in P4 isolated RGCs, relative to mCherry expressing controls (N = 5 or more independently repeated experiments). Data presented as mean expression, + SEM, identified using multiple microarray chips (significance ascribed by one-way ANOVA and Tukey multiple comparison, *p ≤ 0.05). Relative change in mRNA expression of (b) MTP18, (c) KLF9, and (d) KLF7, in isolated RGCs from E17-P12 by microarray. All groups are N = 3 or more independently repeated experiments. All Error bars represented as ± SEM.