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. 2019 Jul 23;9:10645. doi: 10.1038/s41598-019-46378-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of androgen-responsive genes. (A) Androgen-responsive gene expression in male WT zebrafish liver after one week of KT11 treatment. (B) Androgen-responsive gene expression in the F2 male L-ARKO zebrafish liver. (C) Androgen-responsive gene expression in F2 male L-ARKO liver after one week of KT11 treatment. RNA expression of selected genes was determined by RT-qPCR. Fold changes are shown in log₂ scale in comparison to male WT control liver and dash lines indicate +1 and −1 levels. Statistical significance: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, no significant difference.