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. 2019 Jul 23;9:10645. doi: 10.1038/s41598-019-46378-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of liver-specific ar knockout on male kras zebrafish. (A) Kaplan-Meier survival curves of male kras and kras/L-ARKO zebrafish during 14-day Dox treatment. (B,C) Representative images of the gross observations (upper) and liver histology images (lower) from WT, L-ARKO, kras and kras/L-ARKO zebrafish after Dox induction for one week (B) or two week (C). Livers are outlined by a dashed line. (D,E) Quantitative analyses of histological phenotypes of liver sections from the 1-wpi (D) and 2-wpi (E) samples. HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma. Statistical significance between the kras and kras/L-ARKO groups for the incidence of different tumor types: *p < 0.05; ****p < 0.0001; ns, no significant difference.