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. 2019 Jul 17;13:326. doi: 10.3389/fncel.2019.00326

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Copyright © 2019 Quirion and Parsons.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term potentiation (LTP) induced by high-frequency stimulation (HFS) is impaired in Q175FDN mice as early as 6 months of age. (A) Graph of percent potentiation for 1 h following HFS (applied at time = 0) in hippocampal tissue from wild-type (WT; gray) and heterozygous Q175FDN mice (Het; blue) at 6 months of age. Yellow shading indicates the responses that were averaged to quantify post-tetanic potentiation (PTP). Green shading indicates the responses that were averaged to quantify LTP. (B) Individual data points (circles) and mean ± SEM (black lines) of the percent PTP in 6-month-old WT and Het mice. (C) Individual data points (circles) and mean ± SEM (black lines) of the percent LTP in 6-month-old WT and Het mice. Representative traces in panel (A) represent traces obtained during baseline (black), PTP (red) and LTP (blue) for the indicated genotype. Scale bars for the representative traces indicate 2 ms and 0.2 mV. ^*p < 0.05.