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Surgical trauma induces anxiety-like behavior in aged mice. The time in the central area was taken as measures of anxiety and exploratory behavior in the open-field test. (A) Mean velocity. (B) Total travel distance. (C) Rearing activity. (D) Entries into the center. (E) % central area. Data are presented as means ± SEM; *P < 0.05, vs. Control, Student’s t-test, N = 10 for all analyses.
