TABLE 3.

Top 10 GO biological processes of upregulated target genes and top 6 biological processes of downregulated target genes (surgery vs. control).

GO.ID	GO Term	Fold enrichment	P value
Upregulated target genes
GO:0090025	regulation of monocyte chemotaxis	> 12	< 0.01
GO:0033631	cell-cell adhesion mediated by integrin	> 12	< 0.01
GO:0010820	positive regulation of T cell chemotaxis	> 12	< 0.01
GO:0010819	regulation of T cell chemotaxis	> 12	< 0.01
GO:0036230	granulocyte activation	> 12	< 0.01
GO:0002548	monocyte chemotaxis	> 12	< 0.01
GO:2000403	positive regulation of lymphocyte migration	> 12	< 0.01
GO:1902337	regulation of apoptotic process	> 12	< 0.01
GO:0006925	inflammatory cell apoptotic process	> 12	0.011
GO:1901623	regulation of lymphocyte chemotaxis	> 12	0.01
Downregulated target genes
GO:0050805	negative regulation of synaptic transmission	> 5	0.001
GO:0032607	interferon-alpha production	> 5	0.001
GO:0060292	long term synaptic depression	> 5	0.029
GO:0042987	amyloid precursor protein catabolic process	> 5	0.03
GO:1902803	regulation of synaptic vesicle transport	> 5	0.036
GO:0032733	regulation of interleukin-10 production	> 5	0.044