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. 2019 Jul 17;10:804. doi: 10.3389/fphar.2019.00804

Figure 2.

Figure 2

Chronic fluoxetine treatment (28 days) decreased the dendritic length of pyramidal neurons in the motor and auditory cortices (layer II–III). Golgi-stained neurons of the II–III layer of the secondary motor cortex (M2) and the primary auditory cortex (AUD1) were drawn with camera lucida and digitally scanned. (A) and (D) Scheme of the analyzed areas (Paxinos and Watson, 1998). (B) and (E) Representative drawings of neurons obtained from vehicle or fluoxetine-treated animals. In each case, the neuron at the left is from the control (vehicle-treated), while the neuron at the right is from the fluoxetine-treated animal. Scale bar: 20 µm. (C) and (F) Quantifications of the total, apical, and basal dendritic lengths. For each condition, we analyzed at least 10 neurons obtained from three animals per group (in the case of M2) and from three (control) and four (fluoxetine-treated) animals in the case of AUD1. Values represent mean ± SEM. *p ≤ 0.05; **p < 0.01 ***p < 0.001 Mann–Whitney U-test.