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. 2019 Jul 17;11:178. doi: 10.3389/fnagi.2019.00178

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Copyright © 2019 Quan, Qian, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of pioglitazone and Aβ_1–42 on the binding of CDK5 to PPARγ in AD model neurons. (A) Representative immunoblots to show reciprocal co-IP experiments in using anti-CDK5 or anti-PPARγ antibodies. (B) Intergroup comparisons of CDK5 protein levels in immunoprecipitated complexes obtained using anti-PPARγ antibody. (C) Intergroup comparisons of PPARγ protein levels in immunoprecipitated complexes obtained using anti-CDK5 antibody. n = 6 wells per group. *P < 0.05 compared to the control group, ^#P < 0.05 compared to the Aβ group, °P < 0.05 compared to the Pio group.