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. 2019 Jul 17;9:644. doi: 10.3389/fonc.2019.00644

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Copyright © 2019 Kyr, Polaskova, Kuttnerova, Merta, Neradil, Berkovcova, Horky, Jezova, Veselska, Klement, Valik and Sterba.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of individual treatment plans. Figure schematically shows the treatment plans of individual patients. Three shades of gray bars represent periods to the first, second, and third event, respectively, within a patient. Circles, triangles, and crosses indicate irradiation (RT), surgery (SRG), and biologically guided approach commencement (TARG), respectively. Rainbow-like set of active agents is presented to illustrate the complexity of treatment plans in patients with individualized therapeutic approaches. Multiple combinations of different drugs commencing at different time points and changing within an individual patient create unique cases rather than similar groups.