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. 2019 Jul 17;9:644. doi: 10.3389/fonc.2019.00644

Table 3.

Parameter estimates of final multivariate models.

Model Treatment HR p
Conditional frailty (EFS combined) METRO 0.45 0.005
General joint frailty (relapses) METRO 0.46 0.017
General joint frailty (deaths) REPUR/INHIB 0.15 0.004
SURG/RT 0.16 0.001

Final bias-adjusted models from multivariate analysis represented by the most appropriate model (conditional frailty model for EFS and general joint frailty model for joint modeling of relapses and deaths).