Table 1.

Pros and Cons to initiate a NBS program in the developing countries.

Pros and Cons to establish a NBS program in the developing countries
Pros	Cons
•Fast screening of different metabolic disorders	•Requirement of technical staff and advance equipments
•Early diagnosis and treatment	•Every newborn baby should be screened
•Affected patients can live a healthy life	•Which disorders should be a part of NBS and which are not
•Minimize the burden of rare metabolic disorders from the society	•Should know about the incidence of specific disorders according to population
•Cost effective for the population screening	•Huge funding required to initiate a NBS program
•Small quantity of biofluids required for the screening of many disorders	•Specialist required in the field of pediatrics, metabolomics, clinical and biochemical genetics
•Pre-symptomatic diagnosis	•Collaboration with public and private hospitals
•Family planning and prenatal diagnosis	•False positive and unclear results
•Genetic counseling for the carriers of a specific disease	•Delayed diagnosis in case of false negative results