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. 2019 Jul 17;9:255. doi: 10.3389/fcimb.2019.00255

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Copyright © 2019 Ares, Sansabas, Rodríguez-Valverde, Siqueiros-Cendón, Rascón-Cruz, Rosales-Reyes, Jarillo-Quijada, Alcántar-Curiel, Cedillo, Torres, Girón and De la Cruz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The depletion of cholesterol from macrophages lipids rafts increases the K. pneumoniae capsule polysaccharide. (A) Comparison of phagocytic uptake of K. pneumoniae by THP-1 macrophages treated without/with MβCD (methyl-β-cyclodextrin) to deplete cholesterol. Fold change expression (RT-qPCR) of galF (B), wzi (C), and manC (D) genes of K. pneumoniae (extra and intracellular) during the phagocytosis by THP-1 macrophages treated without/with MβCD. Data represent the mean of at least three independent experiments performed in triplicates (mean ± SD). Statistically significant with respect to the WT bacteria grown in LB medium * p < 0.05; *** p < 0.001.