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. 2019 Jul 19;13:2405–2412. doi: 10.2147/DDDT.S153719

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© 2019 Connett.

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Change from baseline in percentage of predicted FEV1: Lumacaftor-ivacaftor (LUM-IVA) versus placebo.

Note: Reprinted from Lancet Respir Med, 5(2), Konstan MW, McKone EF, Moss RB, et al, Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study, 107–118, Copyright 2017, with permission from Elsevier.19).