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. 2019 Jul 19;13:2405–2412. doi: 10.2147/DDDT.S153719

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© 2019 Connett.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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Lumacaftor-ivacaftor (LUM/IVA) treatment effects on projected annual rate of pulmonary exacerbations.

Note: Reprinted from Lancet Respir Med, 5(2), Konstan MW, McKone EF, Moss RB, et al, Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study, 107–118, Copyright 2017, with permission from Elsevier.19