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. 2019 Jul 23;9:10634. doi: 10.1038/s41598-019-46938-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the profile of ICAM-1 expression in tissues of human and mouse. (A) Specificity of anti-mouse ICAM-1 antibody (3E2) by immunostaining was first validated against subcutaneous tumors of 293T cells stably transduced with murine ICAM-1 (mCD54). ICAM-1 staining of the plasma membrane of 293T(mCD54) cells was clearly discerned from little to background staining of stroma cells within and at boundary of tumor. (B) Antibody staining of heart, liver, lungs, and kidneys was shown. (C) ICAM-1 staining was observed in glomeruli endothelial cells of the kidney and alveoli pneumocytes of the lung in mouse tissues. Heart tissue was devoid of specific ICAM-1staining. (D) Similar distribution of ICAM-1 expression in human tissues was observed. ICAM-1 staining of human tissues was obtained from Protein Atlas database (https://www.proteinatlas.org/ENSG00000090339-ICAM1/tissue).