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. 2019 Jul 23;9:10634. doi: 10.1038/s41598-019-46938-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of SSTR2 expression and activation on CAR T cell activity in vitro and in vivo. (A) The level of antibody binding to SSTR2 was measured to assess SSTR2 internalization induced by SSTR2 agonist (lanreotide). (B) E to T assay of AIC100 cells with or without 1 μM of lanreotide against 293T and 8505C cells. The ratio of T cells to target cells was 2.5:1 (n = 3 each for P2 and P3). (C) A weekly measurement of whole body luminescence to detect tumor growth or killing by AIC100 (P2 and P2b) at MTD doses with or without lanreotide. Lanreotide was administered to mice by intraperitoneal injection at days of 9, 19, 23, 34, and 40 post tumor xenograft. n = 5 for AIC100/Lanreotide; n = 3 for AIC100; n = 4 for No T. Significant difference (p = 0.01) for No T vs. AIC100 or AIC100/Lanreotide; no significance for AIC100 vs. AIC100/Lanreotide by one-way ANOVA with Tukey’s multiple comparisons test.