Table 1.
Secondary care diagnostic interval (SCDI) & regression results: Colorectal cancer.
| n (%) | SCDI (days) centiles |
Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|---|---|
| 25th | 50th | 75th | 90th | OR (95% CI) | OR (95% CI) | ||
| Total cohort | 63 958 (100) | 10 | 25 | 52 | 104 | ||
| Age group | p < 0.0001 | ||||||
| <25 | 327 (0.5) | 0 | 1 | 3 | 43 | 0.14 (0.10-0.19) | 0.35 (0.24-0.52) |
| 25-44 | 2 035 (3.2) | 2 | 18 | 55 | 104 | 0.76 (0.69-0.84) | 0.92 (0.81-1.04) |
| 45-49 | 1 524 (2.4) | 8 | 24 | 55.5 | 104 | 0.96 (0.86-1.08) | 0.95 (0.83-1.09) |
| 50-54 | 2 869 (4.5) | 10 | 24 | 52 | 104 | 0.95 (0.87-1.04) | 0.95 (0.86-1.05) |
| 55-59 | 4 261 (6.7) | 11 | 25 | 55 | 105 | 0.99 (0.91-1.07) | 0.95 (0.87-1.04) |
| 60-64 | 6 562 (10.3) | 14 | 25 | 48 | 98 | Reference | |
| 65-69 | 8 575 (13.4) | 13 | 25 | 51 | 103 | 0.99 (0.93-1.05) | 0.96 (0.90-1.04) |
| 70-74 | 9 428 (14.7) | 14 | 26 | 54 | 106 | 1.08 (1.02-1.15) | 1.03 (0.96-1.11) |
| 75-79 | 9 808 (15.3) | 12 | 27 | 58 | 112 | 1.11 (1.04-1.18) | 1.05 (0.98-1.13) |
| 80-84 | 9 279 (14.5) | 10 | 27 | 55 | 104 | 1.09 (1.03-1.17) | 1.08 (1.00-1.16) |
| ≥85 | 9 290 (14.5) | 4 | 20 | 47 | 96 | 0.75 (0.70-0.80) | 0.92 (0.85-0.99) |
| Sex | p = 0.0002 | ||||||
| Male | 35 318 (55.2) | 11 | 25 | 52 | 103 | Reference | |
| Female | 28 640 (44.8) | 9 | 25 | 53 | 105 | 0.99 (0.96-1.02) | 1.07 (1.03-1.11) |
| Ethnicity | p < 0.0001 | ||||||
| White | 57 851 (90.4) | 11 | 25 | 53 | 104 | Reference | |
| Black | 861 (1.4) | 10 | 27 | 56 | 106 | 1.17 (1.03-1.34) | 1.38 (1.18-1.62) |
| Asian | 1 151 (1.8) | 10 | 26 | 61 | 116 | 1.07 (0.95-1.20) | 0.99 (0.86-1.13) |
| Mixed & other | 9 879 (1.5) | 10 | 25 | 50 | 108 | 1.03 (0.91-1.17) | 1.09 (0.94-1.27) |
| Not known | 3 116 (4.9) | 7 | 21 | 42 | 89 | 0.77 (0.71-0.83) | 0.85 (0.78-0.93) |
| Deprivation quintile | p=0.0444 | ||||||
| 1 - least deprived | 14 251 (22.3) | 11 | 25 | 53 | 104 | Reference | |
| 2 | 14 517 (22.7) | 12 | 25 | 53 | 104 | 1.02 (0.97-1.07) | 1.06 (1.00-1.11) |
| 3 | 13 496 (21.1) | 11 | 25 | 53 | 105 | 1.00 (0.95-1.05) | 1.05 (0.99-1.11) |
| 4 | 11 999 (18.8) | 9 | 24 | 51 | 101 | 0.97 (0.92-1.01) | 1.09 (1.03-1.15) |
| 5 - most deprived | 9 596 (15.6) | 8 | 24 | 52 | 105 | 0.93 (0.88-0.98) | 1.07 (1.00-1.13) |
| Stage | p < 0.0001 | ||||||
| 1 | 10 184 (15.9) | 18 | 34 | 75 | 126 | Reference | |
| 2 | 15 212 (23.8) | 13 | 27 | 55 | 105 | 0.67 (0.64-0.70) | 0.81 (0.77-0.86) |
| 3 | 17 189 (26.9) | 13 | 25 | 51 | 100 | 0.61 (0.58-0.64) | 0.72 (0.68-0.76) |
| 4 | 14 892 (23.3) | 5 | 19 | 37 | 80 | 0.38 (0.36-0.40) | 0.56 (0.53-0.59) |
| unknown/other | 6 481 (10.1) | 3 | 19 | 50 | 108 | 0.44 (0.41-0.47) | 0.68 (0.62-0.73) |
| Diagnostic route | p < 0.0001 | ||||||
| Emergency Presentation | 15 469 (24.2) | 1 | 3 | 12 | 37 | 0.17 (0.16-0.18) | 0.18 (0.17-0.19) |
| GP Referral (routine) | 15 183 (23.7) | 31 | 61 | 102 | 143 | 4.31 (4.11-4.53) | 4.43 (4.21-4.65) |
| Two Week Wait | 20 755 (32.4) | 17 | 25 | 38 | 61 | Reference | |
| Inpatient Elective | 2 113 (3.3) | 0 | 6 | 27 | 57 | 0.37 (0.33-0.41) | 0.37 (0.34-0.41) |
| Other Outpatient | 4 092 (6.4) | 18 | 49 | 96 | 145 | 2.23 (2.08-2.40) | 2.19 (2.03-2.35) |
| Screen detected | 6 346 (9.9) | 18 | 27 | 45 | 92 | 1.14 (1.08-1.21) | 1.14 (1.07-1.21) |
| Charlson comorbidity score | p < 0.0001 | ||||||
| 0 | 50 548 (79.0) | 10 | 24 | 48 | 95 | Reference | |
| 1 | 6 395 (10.0) | 11 | 28 | 72 | 128 | 1.30 (1.24-1.37) | 1.31 (1.24-1.40) |
| 2 | 3 660 (5.7) | 11 | 29 | 74 | 133 | 1.33 (1.24-1.42) | 1.37 (1.27-1.49) |
| 3+ | 3 355 (5.3) | 8 | 27 | 70 | 128 | 1.16 (1.08-1.24) | 1.33 (1.22-1.45) |
| Additional diagnostics* | p < 0.0001 | ||||||
| No | 59 394 (92.9) | 9 | 23 | 49 | 101 | Reference | |
| Yes | 4 564 (7.1) | 30 | 50 | 86 | 126 | 4.98 (4.62-5.38) | 4.58 (4.21-4.98) |
Bold text – statistically significant associations.
*
Colorectal cancer additional tests in 6 months before diagnosis - CT Colonography.