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Effect of BSYS on PI3K and Akt protein and mRNA expression in the brain and spinal cord of mice on Days 18 and 40 PI. P-PI3K/PI3K (A and B) and p-Akt/Akt (C and D) protein expression and mRNA were detected by WB and qRT-PCR, as described in the Materials and Methods. Data are represented as the mean ± SE, n = 5 for each group. *P < 0.05, **P < 0.01 vs. NC; # P < 0.05, ## P < 0.01, ### P < 0.001 vs. EAE.
