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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Figure 11.

Figure 11

Nanoscale morphologies that are possible for peptide assemblies: (a) nanofibers, (b) nanosheets, and (c) nanoparticles, imaged by TEM (a and c) or AFM (b). The cross-section in Panel b shows the nanosheet thickness. Scale bars in Panels a, b, and c correspond to 50 nm, 200 nm, and 500 nm, respectively. Reprinted with permission from Reprinted with permission from Cormier, A. R.; Pang, X.; Zimmerman, M. I.; Zhou, H.-X.; Paravastu, A. K. Molecular structure of RADA16-I designer self-assembling peptide nanofibers. ACS Nano 2013, 7, 7562–7572. Copyright 2013 American Chemical Society. Reprinted with permission from Jiang, T.; Xu, C.; Liu, Y.; Liu, Z.; Wall, J. S.; Zuo, X.; Lian, T.; Salaita, K.; Ni, C.; Pochan, D.; Conticello, V. P. Structurally defined nanoscale sheets from self-assembly of collagen-mimetic peptides. J. Am. Chem. Soc. 2014, 136, 4300–4308. Copyright 2014 American Chemical Society. Tian, Y.; Zhang, H. V.; Kiick, K. L.; Saven, J. G.; Pochan, D. J. Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide. Org. Biomol. Chem. 2017, 15, 6109–6118. Copyright 2017 Royal Society of Chemistry.