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. Author manuscript; available in PMC: 2019 Dec 26.
Published in final edited form as: Chem Rev. 2018 Oct 3;118(24):11519–11574. doi: 10.1021/acs.chemrev.8b00038

Figure 16.

Figure 16

Structure of tetrameric LacI-Osym assembly with domains labeled (left). LacI monomer topology and domain structure (right). Note that the topology of folding involves three cross-overs between the N- and C-subdomains.